In particular, compound 95 served as probably the most efficacious on the shortlisted compounds within an HCT116 tumor xenograft design, which also could inhibit The expansion of a broad panel of human cancer cell strains such as breast, ovarian, colon, prostate, lung and melanoma cell lines.-indazole derivatives with disubstituent groups at both e
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Substitution at R3 by using a halogen or alkoxy group (74f–74i) brought about a slight increase in mobile potency Using the halide analogs (74g–h) showing best the potency inside the group. Even further optimization brought about the discovery of 74i–j, with 74k as essentially the most active compound during the sequence (pIC50 = six.77) with
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